Fig. 2.

Arginase inhibition or EC-A1 deletion prevents HFHS-induced increased in expression of cytokines, chemokines and adhesion molecules in isolated aortic endothelial cells. Effects of ABH and EC-A1 deletion on protein levels of the proinflammatory cytokine tumor necrosis factor-$\mathrm{\alpha }$ (TNF-$\mathrm{\alpha }$; A), the chemokine monocyte chemoattractant protein-1 (MCP-1; B), anti-inflammatory interleutin-10 (IL-10; C), adhesion molecules vascular cell adhesion molecule-1 (VCAM-1; D), and intercellular adhesion molecule 1 (ICAM; E). Values are means ± SE; n = 6 mice. *P < 0.05 vs. WT ND or A1^con ND groups.