Fig. 8.

Renal autoregulation is efficient in neonatal pigs, and dependent on L-type Ca²⁺ channels. A: traces illustrating that an increase in mean arterial pressure (MAP) by 20 mmHg induces autoregulation of renal blood flow (RBF) and renal cortical perfusion in neonatal pigs. B: traces showing that intrarenal arterial infusion of nicardipine (1 µg·kg⁻¹·min⁻¹; 30 min) abolishes RBF and renal cortical perfusion autoregulation in neonatal pigs. C: bar graphs summarizing mean (n = 4 each) RBF and renal cortical perfusion autoregulation indexes in the absence and presence of nicardipine. RCoP, renal cortical perfusion; *P < 0.05 vs. control.