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Proposed signaling pathway between TRPC6 activation and TRPC5 externalization. Ca2+ entry through TRPC6 activates a kinase, leading to ERK phosphorylation. ERK then phosphorylates p47phox, leading to NADPH oxidase activation and production of ROS, which contribute to the phosphorylation of MLCK that is required for externalization of TRPC5. The components of this process may be localized in a “signalsome” of the plasma membrane (PM).
