Fig. 4.

Ouabain resistance attenuates transaortic constriction (TAC)-induced cardiac hypertrophy. The effects of 4 wk of TAC (black bars) versus sham surgery (white bars) was compared in wild type (WT; α₁^R/Rα₂^S/S), ouabain-resistant (α₁^R/Rα₂^R/R), and SWAP (α₁^S/Sα₂^R/R) mice. Left ventricular (LV) structure and function were measured by echocardiography. Results (shown as means ± SE; n values on LVEDD bars apply to all graphs) were analyzed by two-way ANOVA; groups were compared post hoc using Tukey’s test. LVEDD, LV end-diastolic diameter; LVESD, LV end-systolic diameter; AWth, anterior wall thickness; EF, ejection fraction. *P < 0.05 vs. the corresponding sham; †P <0.05 vs. TAC WT and TAC α1^R/Rα2^R/R. [Reproduced from Ref. 112 with permission.]