Table 1.

Physical characteristics of the experimental animals

	Number of Animals/Group	Body Weight, g	Uterine Weight, g	Heart Weight, g	Uterine Weight/Body Weight, %	Heart Weight/Body Weight, %	Serum E2, pg/ml
Sham	9	784.00 ± 85.00	1.52 ± 0.47	2.38 ± 0.08	0.19 ± 0.05	0.31 ± 0.04	7.80 ± 4.37
OVx	10	870.00 ± 67.00*	0.37 ± 0.08†	2.66 ± 0.23†	0.04 ± 0.01†	0.31 ± 0.02	4.19 ± 1.93*
OVx + E	10	711.00 ± 57.00*	3.89 ± 0.60†	2.48 ± 0.13	0.55 ± 0.10†	0.35 ± 0.04*	24.22 ± 3.83†

Values are expressed as means ± SD. Sham, sham operation; OVx, ovariectomy; OVx + E, OVx with 17β-estradiol treatment.

^*P < 0.05 and

^†P < 0.001 represent significant differences compared with the sham group (by one-way ANOVA and Fisher’s test).