Table 2.
Smmary of studies related to GPCRs, their associated miRNAs, and their proposed physiological roles in gastrointestinal studies
| Function | miRNA | Association with GPCR | Ref. No. |
|---|---|---|---|
| Proliferation | miR-142–3p | Regulate CD133, ABCG2, and LGR5 | 111 |
| miR-34a | Regulate PAR2-induced CyclinD1 | 84 | |
| Monocytes/immune tolerance | miR-525–5p | Negatively regulates VPAC1 receptor expression | 24 |
| Angiogenesis | miR-802 | Regulates AT1 receptor expression | 106 |
| miR-27b, miR-218a | Regulates A2B receptor expression | 60 | |
| miR-100 | Inhibit LGR5 expression | 136 |
LGR5, leucine-rich repeat-containing G protein-coupled receptor 5; PAR2, protein-activated receptor 2; VPAC1, vasoactive intestinal peptide receptor 1; AT1, angiotensin II receptor type 1; A2B, adenosine A2b receptor. Bold type indicates GPCRs.