Table 1.
Participant baseline characteristics and effects of aprepitant and placebo on the primary end points
| Data Median (IQR) |
|||
|---|---|---|---|
| Aprepitant | Placebo | P Value | |
| n | 12 | 12 | |
| Demographics | |||
| Sex (F:M) | 8:4 | 9:3 | 0.653 |
| Age, yr | 34.5 (30.5, 47.0) | 34.5 (27.0, 47.5) | 0.840 |
| BMI, kg/m2 | 26.6 (25.3, 28.8) | 23.8 (23.0, 28.7) | 0.273 |
| Gastric functions | |||
| Gastric emptying solids T1/2, min | 95.4 (85.7, 114.0) | 99.8 (85.6, 120.0) | 0.453 |
| Fasting GV, ml | 191.8 (158.7, 216.4) | 174.1 (136.6, 187.9) | 0.037 |
| Postprandial GV, ml | 675.5 (577.8, 746.9) | 618.4 (590.6, 648.6) | 0.004 |
| Accommodation GV, ml | 476.1 (395.4, 531.3) | 457.2 (429.1, 502.5) | 0.047 |
| Satiation (Ensure) drink test | |||
| VTF, ml (= kcal) | 630.0 (420.0, 750.0) | 420.0 (345.0, 555.0) | 0.248 |
| MTV, ml (= kcal) | 1007.0 (886.8, 1066.5) | 808.0 (711.0, 1046.5) | 0.099 |
| Aggregate score (/400) | 179.5 (164.5, 231.0) | 119.5 (98.5, 169.5) | 0.020 |
| Nausea score (/100) | 36.0 (19.0, 48.5) | 4.0 (1.0, 8.5) | 0.023 |
Shown are the primary end points of gastric half-emptying time (T1/2) of solids and gastric volume (GV), assessed incorporating sex difference and body mass index (BMI) in the analysis, as well as the secondary end points of fasting and postprandial GVs and measurements related to satiation. There was no significant group difference in gastric emptying of solids, while the higher accommodation volume with aprepitant was significant. IQR, interquartile range; VTF, volume to fullness; MTV, maximum tolerated volume.