Table 1. Descriptions of the genes deleted from the wild-type background.

RLS values for the gene-deleted strains are given in mean ± SD generations. Wild-type cells lived 23.5 ± 8.1 generations. n = 200 cells.

Gene	Description	Lifespan
SIR2	NAD+-dependent histone deacetylase of the sirtuin family.	14.0 ± 4.8
RIF1	Protein involved in telomere length control, silencing, and DNA replication.	15.4 ± 5.0
TVP15	Integral membrane protein. Localizes to late Golgi vesicles.	19.0 ± 7.5
SGF73	Protein with roles in anchoring deubiquitination module into SAGA and SLIK complexes.	33.2 ± 13.0
TOR1	PIK-related protein kinase and rapamycin target. Subunit of the TORC1 complex.	30.0 ± 10.7
GPA2	Nucleotide binding α subunit of the heterotrimeric G protein.	28.3 ± 8.5
FOB1	Nucleolar protein that is required for replication fork blocking.	31.9 ± 11.8