FIG. 2.

Load/displacement measurements. The adhesion of mesothelium to the pectin-based bioadhesive was assessed by three factors: (A) tensile strength, (B) peel strength, and (C) shear resistance. The tissue was applied—with ∼0.1 N force and 3–5 min development time—to the firm pectin-based substratum that was composed of 50% pectin and 50% CMC. Loads were applied at a controlled rate to a suture passed through the tissue within 2 mm of the adhesive interface. The lung demonstrated tensile strength (A) greater than peel strength (B) or shear resistance (C). The adhesion of lung to equal weight % pectin and CMC is shown. Notably, peel and shear forces applied to the lung demonstrated near-interface parenchymal separation (yield point) that facilitated the isolation of the pleural mesothelium. The results represent median values of N = 5 replicates. CMC, carboxymethylcellulose.