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. 2018 Feb 15;1681:64–74. doi: 10.1016/j.brainres.2017.12.036

Fig. 3.

Fig. 3

LPS-induced decrease of prefrontal frequency and amplitude. (A) Theta power spectral density recorded from the medial prefrontal cortex (mPFC) visualized for control saline injection (light blue), 1.5 h after LPS injection (orange), 3 h (grey), 4 h (yellow), 6 h (blue), 8 h (green) and 24 h (dark blue). (B) Peak prefrontal theta frequency (Hz) for controls and LPS injected animals. (C) 10 s epochs of two LFP traces recorded from mPFC in control (top) and LPS-injected animals (below) 1.5, 3, 4, 6, 8 and 24 h after the injection of LPS. (D) mPFC theta frequency visualized for control saline injection (light blue), 1.5 h after LPS injection (orange), 3 h (grey), 4 h (yellow), 6 h (blue), 8 h (green) and 24 h (dark blue). The results are grouped in speed-bands of 2 cm/s: 0–2 cm/s, 2–4 cm/s, 4–6 cm/s, 6–8 cm/s, 8–10 cm/s. Bonferroni post hoc test **P < .01, *P < .05, (E) Color-coded spectrograms of the probability of theta frequency at different speeds. Left panel shows representative probability spectrogram from the baseline recording, while the right probability spectrogram – from recording 3 h after the LPS administration. (F) Relative mPFC theta amplitude measured with the ratio of baseline over injection recording for different speed ranges. Bonferroni post hoc test ***P < .001, **P < .01. Error bars, mean ± s.e.m. (G) Color-coded spectrograms of the probability of theta amplitude at different speeds. Left probability spectrogram: baseline recording; right – 3 h post LPS injection recording.