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. 2018 Feb 1;24(3-4):287–300. doi: 10.1089/ten.tea.2016.0535

FIG. 8.

FIG. 8.

Therapeutic potential of ECTs in a rat model of MI. Myocardial fibrosis (A, B) and capillary density (C) in the peri-infarct area 4 weeks after ECT transplantation was assessed by using Sirius Red staining and immunohistochemistry, respectively. (D) HGF, SDF-1, and VEGF expression in the peri-infarct area of the native myocardium at 4 weeks after ECT transplantation was assessed by real-time PCR. Electrical integrity of the grafted ECT in the native heart was assessed in Langendorff-perfused hearts from rats transplanted with GCAMP2-expressing ECTs. (E) Electrical coupling between the native heart and transplanted ECT (dashed line) was analyzed by detection of Ca2+ transient (GCAMP2) and membrane potential (RH-237). Representative images of hearts transplanted with ECTs containing 70% cardiomyocytes. Scale bars: 50 μm. *p < 0.05; **p < 0.01. HGF, hepatocyte growth factor. Color images available online at www.liebertpub.com/tea