Fig. 6. Effects of Perilla frutescens (L.) Britton var. (PF) sprout extract on AMPK phosphorylation and gluconeogenic protein expression in db/db mice.

Western blot analysis for (A) AMPK phosphorylation and (B) G6Pase and PEPCK in db/db mice liver lysates. These data are representative of three independent experiments. Results were normalized by total AMPK and β-actin. Data are expressed as mean ± SD (n = 5-10). ^**P < 0.01 and ^***P < 0.001 vs. ND. ^##P < 0.01, and ^###P < 0.001 vs. DM group. ND, non-diabetic; DM, diabetes mellites; PF, Perilla frutescens; PC, positive control; p-AMPK, phosphorylated-AMPK; AMPK, AMP-activated protein kinase; G6Pase, glucose-6-phosphatase; PEPCK, phosphoenolpyruvate carboxykinase.