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. 2017 Dec 7;103(2):221–230. doi: 10.3324/haematol.2017.175810

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Figure 2. — Treatment algorithm for immune-mediated PRCA in our patient cohort. Cyclosporine or cyclophosphamide with a steroid taper is the first-line choice of treatment in both idiopathic and LGL- related PRCA. Maintenance treatment with immunosuppressive therapy is usually needed, and varies based on the sustainability of the response obtained (see text for details). Methotrexate is used in a salvage setting in LGL/PRCA, but has no role in idiopathic PRCA. Alemtuzumab is one of the commonly used salvage options in refractory PRCA.