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. 2017 Dec 7;103(2):221–230. doi: 10.3324/haematol.2017.175810

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Figure 3. — Response probabilities across various treatment options in aPRCA. (A) Cyclosporine and tacrolimus are the most effective drugs for PRCA in our cohort. The details of IVIG response rates are elaborated in Table 3. Rituximab is used only in the salvage setting when the front-line options have failed, including commonly used salvage treatments such as alemtuzumab. ATG is used purely as a salvage option, but only shows mediocre, but acceptable, response rates. The other salvage treatment options include danazol, mycophenolate mofetil, bortezomib, erythropoietin, abatacept (Orencia), and tofacitinib (Xeljanz) etc., all of which show good response rates when used in the right setting (see text for details). (B) Response proportion for different treatment options: comparison between LGL vs. non-LGL PRCA groups. Cyclosporine and tacrolimus show better RR in the non-LGL group, whereas campath (alemtuzumab), though not statistically significant, works better in LGL-PRCA. Patients with parvovirus PRCA, and those presenting with low immunoglobulin levels in PRCA show excellent RR with IVIG (see also Table 3).