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. 2017 Oct 27;103(2):361–372. doi: 10.3324/haematol.2017.178608

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Figure 2. — Hypoxanthine negatively correlates with post-trasfusion recovery of using mouse and human red blood cells. (A) Hypoxanthine accumulation is observed in stored C57BL/6J mouse RBC. (B) Transfusion into GFP-RBC mouse recipients (sorting of fluorescence negative RBC) or ⁵¹Cr labeling of human RBC was performed to determine 24 h PTR in mice (n=79) and human volunteers (n=52), whereas paired samples were used to determine hypoxanthine levels. (C, D) Negative correlations were observed for mouse (C) and human RBC hypoxanthine levels and 24 h PTR. Linear and quadratic Spearman correlations as well as their levels of significance are shown for mouse (median across strains) and (D) human data.