Table 2.
Baseline Neuropsychological assessment, Intention to Treat (N=45)
| Placebo | Paroxetine | Fluconazole | Paroxetine + Fluconazole | |
|---|---|---|---|---|
| N=11 | N=11 | N=11 | N=12 | |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
| CalCAP Choice Reaction time Z * | −0.72 (1.25) | −1.94 (3.01) | −0.63 (1.57) | −0.84 (1.50) |
| CalCAP Sequential Reaction Time Z * | −0.24 (0.91) | −0.43 (1.41) | −0.48 (1.25) | −0.03 (1.23) |
| Symbol Digit Z * | 1.26 (1.01) | 0.24 (1.57) | −0.20 (1.60) | 0.91 (1.06) |
| Trail Making Part A Z | 0.59 (0.83) | 0.25 (1.08) | 0.21 (1.38) | 0.67 (1.26) |
| Trail Making Part B Z | 0.47 (1.01) | 0.19 (0.87) | 0.44 (1.37) | 0.24 (1.29) |
| Timed Gait Z ** | −0.61 (1.66) | −2.31 (3.12) | −1.08 (2.75) | −0.91 (1.26) |
| Grooved Pegboard Dominant Z | 0.17 (0.95) | −0.46 (1.15) | −0.47 (1.23) | −0.12 (1.04) |
| Grooved Pegboard Non- Dominant Z | −0.27 (0.96) | −0.55 (1.25) | −0.85 (0.95) | 0.13 (1.22) |
| Hopkins Auditory Verbal Learning test Total Z | −0.80 (1.03) | −0.97 (0.94) | −0.99 (1.09) | −1.18 (1.32) |
| Hopkins Auditory Verbal Learning Test Delayed Z | −1.47 (1.30) | −1.45 (1.75) | −2.27 (1.76) | −1.60 (1.78) |
| Rey Complex Figure Copy Z * | −0.85 (0.97) | −1.08 (1.54) | −1.12 (1.49) | −1.71 (1.60) |
| Rey Complex Figure Delayed Z * | 0.00 (0.56) | −0.55 (0.85) | −0.42 (0.78) | −0.31 (0.82) |
| Stroop Color Interference Z ** | −0.36 (1.553) | −1.85 (2.05) | −2.08 (1.65) | −0.70 (1.55) |
| Letter number sequencing Z * | −0.63 (0.86) | 0.17 (0.62) | −0.3 (1.46) | −0.11 (0.73) |
| FAS verbal fluency Z * | 0.51 (1.17) | −0.10 (0.79) | 0.06 (0.59) | 0.48 (0.89) |
| NPZ8 *** | 0.13 (0.47) | −0.26 (0.71) | −0.28 (0.86) | −0.09 (0.57) |
| GDS *** | 0.49 (0.41) | 0.86 (0.51) | 0.90 (0.78) | 0.68 (0.46) |
*
Sample size (n) for this test: placebo n=11, paroxetine n=10, fluconazole n=11, paroxetine and fluconazole n=12
**
Sample size (n) for this test: placebo n=11, paroxetine n=9, fluconazole n=11, paroxetine and fluconazole n=12
***
Sample size (n) for this test: placebo n=10, paroxetine n=10, fluconazole n=9, paroxetine and fluconazole n=11
CalCAP-California Computerized Reaction Time test
GDS-Global deficit score