Figure 1. C. elegans muscle specific mitochondrial fragmentation with age.

Both the nucleus and the mitochondria within a muscle cell of C. elegans are seen here. The quality of mitochondria can be assessed by the relative morphology and connectivity.In healthy organisms, mitochondria are maintained as a network in muscle cells and other cells, which increases efficiency. This network can be compromised as the organism naturally ages and in premature aging diseases (progeria). This fragmentation of mitochondrial network is associated with decreased healthspan, and is likely tied to mitophagy and other mitochondrial quality control processes. Compounds that alleviate this excessive fragmentation may improve muscle health. (I realy like this images, so clear. I think, it will be nice to include also some with e.g. tomatodin or NR treatment for confirming this reviews contents, if it’s possible)