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. 2018 Jan 31;8:1968. doi: 10.1038/s41598-018-20171-0

Figure 1.

Figure 1

Absence of a retinal phenotype in pigmented (C57Bl/6J genetic background) Ush1c−/− and Ush1g−/− mice. (a–d) Electroretinogram (ERG) measurements performed at month 12 on wild-type control (grey), Ush1g−/− (red) and Ush1c−/− (blue) C57Bl/6 J mice showing no significant difference in the amplitudes of ERG responses, regardless of the test conditions: dark-adapted (a and b), photopic (c) or flickers (d). (e,f) OCT scans reveal no difference in retinal layers thickness of C57Bl/6 J Ush1g−/− mice (f) compared to control mice (e). In the retina of Ush1g−/− and Ush1c−/− C57Bl/6 J mice, the immunolabeling for cone blue opsin is well restricted to unaffected outer segments (h,i), resembling those observed in control mice (g). The scale bars represent 50 µm in (e and f), and 10 µm in (g–i).