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. 2018 Jan 31;8:1968. doi: 10.1038/s41598-018-20171-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Photoreceptor apoptosis in Ush1g^−/− BALB/cJ mice. (a–d) TUNEL staining in wild-type (a) and Ush1g^−/− (b–d) BALB/cJ mice at 3 mo. Apoptotic cells (labeled in red) are detected in the outer nuclear layer (ONL) of Ush1g^−/− BALB/cJ retina (b–d), whereas such cells were completely absent from the retina of control BALB/cJ mice (a). Note the apposition of the TUNEL labeling and the mislocalized S opsin immunolabeling (white arrowhead, d). The scale bars represent 50 µm in (a and b), 20 µm in (c), and 15 µm (d). OS: outer segment, INL: inner nuclear layer, IPL: inner plexiform layer.