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Estradiol does not modulate glutamatergic transmission to AVPV kisspeptin neurons from KERKO mice. A, B, Representative spontaneous (A) and miniature (B) postsynaptic currents in AVPV kisspeptin neurons in OVX and OVX+E groups in control and KERKO mice. C, Individual values and mean ± SEM sEPSC (left) and mEPSC (right) frequency. D, Individual values and mean ± SEM sEPSC (left) and mEPSC (right) amplitude. *p < 0.05 (two-way ANOVA/Holm–Sidak).
