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. 2018 Jan 31;8:1963. doi: 10.1038/s41598-018-20385-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reversible temperature dependent swelling/shrinkage of PNIPAAm hydrogel. (a) Equilibrium swelling of PNIPAAm depends on temperature. Swelling ratios of PNIPAAm during a heating cycle match well with those from a cooling cycles. Also, experimental results are in a good agreement with the equilibrium swelling simulation result. (b) Low temperature swelling and high temperature shrinkage of PNIPAAm occurred repeatedly when heated and cooled alternately between 10 °C and 50 °C.