Fig. 3.

Clinical course in Case 2.

Lusutrombopag led to an increase in platelet count. The patient developed severe disseminated intravascular coagulation (DIC) post-partial splenic embolization (PSE), and severe thrombocytopenia and increases in fibrinogen degradation products and thrombin-antithrombin complex (TAT) levels were noted. TAT increased from 4.5 ng/ml to more than 120 ng/ml on day +1 and remained this high until day +7. DIC was resolved with medication and platelet transfusion. After cure of DIC, the platelet count became higher than the value obtained on admission.