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. 2018 Jan 31;8:1941. doi: 10.1038/s41598-018-20277-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The image shows adhesive progenitors of OSCs in culture. The bar indicates 50 μm. (B) The image shows the reactivity of progenitors of OSCs with STEM101 in the nuclei. STEM101 (red) and Hoechst (blue) are co-expressed in all cells. The bar indicates 50 μm. (C) The image shows progenitors of OSCs dissociated into single cells with trypsin. The size of the cells is 10–25 μm. The bar indicates 50 μm. (D) Image of OSCs immunostained with CX30 (red). Nuclei were counterstained with Hoechst (blue). (E) Image of OSCs immunostained with PENDRIN (green). Nuclei were counterstained with Hoechst (blue). (F) Merged image of (D) and (E). Red: CX30; Green: PENDRIN; Blue: nuclei. Scale bars indicate 50 μm. (G) The graph shows percentages of cells positive for otic markers (PAX2, PAX8, and SOX2) among OPCs and progenitors of OSCs in vitro. (H) The graph shows percentages of CX30-positive cells in OPCs, progenitors of OSCs, and OSCs in vitro.