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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2017 Sep 2;133:11–19. doi: 10.1016/j.prostaglandins.2017.08.010

Table 2.

Effectiveness of PUFA supplementation in anorexia nervosa.

Authors, (Study location) Ref Subject and design Intervention Outcome variables Key Findings
Ayton et al. (United Kingdom) [46] 1 patient with severe AN 1 g/day EPA for 3 months Changes in physical and psychological measures After 3 months, weight (from 45.2 to 57) and food intake (from 1.6 to 8.2), and mood improved, and no relapse for the next 6 months.
Ayton et al. (United Kingdom) [47] 7 AN patients aged 13–22 were followed for at least 3 months 1 g/day EPA versus standard treatment BMI All patients increased in body mass index
Mauler et al. (Germany) [48] 15 AN enrolled. 7 were on n-3 PUFA rich diet and 8 were on SFA diet (control diet) for 5 weeks. n-3 PUFA rich diet versus saturated fatty acids rich control diet Leptin, insulin, ghrelin, and weight gain. No significant difference in leptin and insulin increase, ghrelin decrease, and efficiency of weight gain between two types of diet.