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. 2017 Dec 22;15(3):2655–2660. doi: 10.3892/etm.2017.5675

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Figure 4. — miR-15 inhibits activation of the NF-κB signalling pathway. (A) miR-15 decreased the transcriptional activity of NF-κB. (B) Levels of BCL-2 and BCL-XL mRNA were decreased in miR-15 upregulated colon cancer cells as determined by RT-qPCR. (C) miR-15 inhibited the expression of p50 as determined by the dual-luciferase assay. (D) The expression of p50, BCL-2 and BCL-XL was decreased in miR-15 upregulated colon cancer cells as indicated by the results of western blot analysis. Values are presented as the mean ± standard deviation. miR-15, microRNA-15; NF-κB, nuclear factor κB; BCL-2, B cell lymphoma-2; BCL-XL, B cell lymphoma-extra large; RT-qPCR, reverse transcription quantitative polymerase chain reaction.