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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Anaerobe. 2017 Oct 12;48:249–256. doi: 10.1016/j.anaerobe.2017.10.006

Fig. 7. Comparison of the in vivo toxicity of TcdB variants.

Fig. 7

A) Clinical scores of mice treated with TcdB variants for 24 h. The scores were assessed according to the criteria in Table 2; B) Survival curve. Mice were monitored for survival for 72 h. Mice with a score equal to or higher than 11 were considered moribund and were euthanized (n = 10 per group) B5: TcdB 5 µg; B027-5: TcdB027 5 µg; BM68-5: TcdBM68 5 µg *: p < 0.05, vs PBS; **: p < 0.01, vs PBS; ***: p < 0.001, vs PBS.