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. 2018 Jan 10;3(1):273–285. doi: 10.1021/acsomega.7b01472

Figure 7.

Figure 7

(A) Sequential AFM height images taken in-solution of supported TBLE bilayers enriched with either 5 or 10% GM1 exposed to htt-exon1(51Q). Blue rectangles identify the same region of the surface in the sequential images. Black arrows indicate fibrillar aggregates. (B) Zoomed-in AFM images demonstrating the rough, grainy morphological changes induced in TBLE bilayers enriched in GM1. Blue arrows indicate oligomeric aggregates. (C) Height and volume histograms of oligomeric aggregates observed on TBLE bilayers enriched with GM1 presented as a function of time. To ease visualization, the histograms were normalized for each time point by setting the value of the most common height or volume to 1.