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. 2018 Jan 31;3(1):e00421-17. doi: 10.1128/mSphere.00421-17

FIG 5 .

FIG 5 

Treatment of mice with IL-12/ms during primary infection with N. gonorrhoeae FA1090 induces resistance to reinfection with homologous (FA1090) or heterologous (MS11) strains and induces immune responses to either strain. (A, left) Recovery (mean CFU ± SEM; n = 8) of N. gonorrhoeae on vaginal swabs after reinfection with strain FA1090 or MS11 as shown. Curves that are significantly different (P < 0.01 by ANOVA) are indicated by an asterisk. (Right) Percentage of animals remaining infected at each time point (P < 0.001 and <0.005 by Kaplan-Meier analysis), comparing treatment with IL-12/ms versus blank ms, for reinfection with FA1090 and MS11, respectively. (B) Vaginal IgA and IgG antibodies after clearance of secondary infection tested against strain FA1090 or MS11. (C) Serum IgA and IgG antibodies after clearance of secondary infection tested against FA1090 or MS11. (D) Production of IFN-γ, IL-4, and IL-17 by ILN CD4+ cells recovered after clearance of secondary infection. In panels B, C, and D, values for mice treated with IL-12/ms that are significantly different (P < 0.01 by Student’s t test) from the values for mice treated with blank ms are indicated by an asterisk.