Figure 5.

Interactive cytotoxic effects of binary combinations of AFM1 and OTA in differentiated Caco-2 cells after exposure for 48 h (a–h). After the exposure to mycotoxins, TEER, FITC-dextran (4 and 40 kDa) paracellular flux, and TJ protein expression were measured. There were no significant interactive effects for claudin-3, occludin, and ZO-1 expression. Data are expressed as a percentage of the untreated control for each parameter. White bars represent the measured values, and dark bars represent the expected values. * p < 0.05; ** p < 0.001; *** p < 0.000 represent both significant synergistic and antagonist effects.