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. 2018 Jan 7;10(1):34. doi: 10.3390/toxins10010034

Figure 3.

Figure 3

Interaction of rocuronium with muscle and neuronal nAChRs. Inhibitory curves of rocuronium action on ACh (30 and 10 μM)-evoked intracellular calcium concentration ([Ca2+]i) rises in neuroblastoma Neuro2a cells expressing (a) muscle α1β1εδ and (b) α7 nAChRs, respectively. Inhibition of [Ca2+]i amplitude rise induced by Nic (100 μM) in neuroblastoma SH-SY5Y cells expressing α3-containing nAChRs by different concentrations of rocuronium (c). Each point represents data obtained from 4 independent experiments (mean ± SEM).