Skip to main content
. 2018 Jan 13;10(1):42. doi: 10.3390/toxins10010042

Table 6.

Differential expression (DE) of genes from major enzyme groups responsible for metabolizing xenobiotic chemicals.

ID EW AFB vs. CNTL DT AFB vs. CNTL CNTL EW vs. DT AFB EW vs. DT Description
FDR Pval log2FC FDR Pval log2FC FDR Pval log2FC FDR Pval log2FC
AKR1D1 0.9964 0.0559 0.0000 −2.6518 0.0000 −3.2445 0.2276 −0.5988 aldo-keto reductase family 1, member D1
ALDH2 0.0190 −0.8404 0.0000 −1.5779 0.1522 −0.5354 0.9648 0.1539 aldehyde dehydrogenase 2 family (mitochondrial)
AOX1 0.0000 2.1137 0.0010 0.8410 0.0574 −0.6975 0.2037 0.5258 aldehyde oxidase 1
COMT 0.0000 −2.5729 0.0000 −2.8723 0.0373 −0.7682 0.2064 −0.5319 catechol-O-methyltransferase
CYP1A5 0.0000 −6.0043 0.0000 −9.2792 0.0721 −0.8105 0.0000 2.4042 cytochrome P450, family 1, subfamily A, polypeptide 5
CYP3A37 0.0640 −0.9576 0.0000 −2.8884 0.0007 −1.5099 0.8268 0.3698 cytochrome P450 3A37
CYP3A80 0.9731 −0.1270 0.0052 −1.0866 0.0022 −1.7031 0.3001 −0.8022 cytochrome P450 3A80
EPHX1 0.0000 3.0994 0.0007 0.9636 0.2271 −0.8719 0.0009 1.2112 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 0.0000 −2.7512 0.0000 −2.5788 0.4757 0.4301 0.8342 0.2075 epoxide hydrolase 2, cytoplasmic
EPHX4 0.0000 3.1365 0.0091 2.4479 1.0000 0.3859 0.1409 1.0154 epoxide hydrolase 4
GSTA1.1 * 0.0000 −2.0007 0.0000 −2.6584 0.0066 1.3021 0.0000 1.9010 glutathione S-transferase alpha class A1.1
GSTA1.3 * 0.0004 −1.0804 0.0000 −1.6746 0.1740 0.6098 0.0003 1.1419 glutathione S-transferase alpha class A1.3
GSTA2 0.0000 −1.7332 0.0000 −1.9211 0.1019 0.5386 0.0098 0.6713 glutathione S-transferase 2
GSTA3 0.8469 0.1297 0.0014 1.4667 0.0000 2.3130 0.0063 0.9211 glutathione S-transferase 3
GSTA4 0.0000 −5.9578 0.0000 −6.4058 0.3086 0.5690 0.0204 0.9569 glutathione S-transferase 4
GSTK1 0.0000 −1.8072 0.0000 −2.9850 0.1814 −0.5583 0.0773 0.5713 glutathione S-transferase kappa 1
GSTZ1 0.0000 −3.3639 0.0000 −4.1131 1.0000 0.0517 0.0325 0.7477 glutathione S-transferase zeta 1
LOC100538434 0.0000 1.7178 0.7570 0.1451 0.0038 −0.9746 0.3530 0.5480 cytochrome P450 4B1-like
LOC100538440 0.0000 −2.8970 0.0000 −2.2682 0.1163 0.5550 0.9682 −0.1256 glutathione S-transferase theta-1-like
LOC100538588 0.0025 −1.1881 0.0000 −3.4884 0.0001 −1.2845 0.0758 0.9622 cytochrome P450 4B1-like
LOC100538595 0.0000 −7.0046 0.0000 −8.5660 1.0000 0.0523 0.1895 1.5495 glutathione S-transferase theta-1
LOC100542486 0.0000 −3.3050 0.0000 −7.4005 0.1187 −0.8954 0.0000 3.1496 cytochrome P450 1A4
LOC100543147 0.0000 −1.9129 0.0001 −1.0244 0.0097 0.8235 0.9927 −0.1181 cytochrome P450 2U1
LOC100543474 0.0000 4.4089 0.0000 3.2044 0.6256 −0.4228 0.0227 0.7294 glutathione S-transferase omega-1-like
LOC100544448 0.0000 −3.1080 0.0000 −3.1865 1.0000 −0.1757 1.0000 −0.1579 cytochrome P450 2C9-like
LOC100544938 0.0000 −1.6254 0.0052 −0.8255 0.8684 0.3729 0.3538 −0.4894 cytochrome P450 26B1
LOC100545163 0.0000 −2.7394 0.0000 −3.5785 0.0404 −0.7668 1.0000 0.0207 alcohol dehydrogenase 1
LOC100545251 0.0055 −0.8765 0.0000 −1.7618 0.6466 0.3201 0.0085 1.1514 sulfotransferase 1C1-like
LOC100545313 0.0011 −6.6206 0.0000 −12.9085 0.0662 2.5030 0.0071 9.2625 sulfotransferase 6B1-like
LOC100545337 0.0042 −0.8258 0.4111 0.3711 0.0116 1.3434 1.0000 0.0879 sulfotransferase family cytosolic 2B member 1-like
LOC100545469 0.0000 −7.4792 0.0000 −12.4538 0.8899 −0.3159 0.0330 4.6071 sulfotransferase 6B1-like
LOC100545683 0.0000 −2.4276 0.0000 −5.5488 0.3422 −0.8455 0.0915 2.2195 cytochrome P450 2H1-like
LOC100546724 0.0000 1.8339 0.0095 0.8064 0.1178 −0.9930 1.0000 −0.0121 cytochrome P450 2K4-like
LOC100546874 0.0169 0.7907 0.0000 0.9012 1.0000 0.0100 0.9251 −0.1538 cytochrome P450 2W1-like
LOC100547030 0.0000 −7.6458 0.0000 −13.6234 1.0000 −0.2262 0.0010 5.8718 cytochrome P450 2W1-like
LOC100547576 0.0000 −4.3115 0.0000 −5.2719 0.0014 −1.0131 1.0000 −0.1127 UDP-glucuronosyltransferase 1-1-like
LOC100547627 0.7689 0.1433 0.0094 −0.7229 0.0023 −1.0592 0.7311 −0.2480 sulfotransferase family cytosolic 1B member 1
LOC100547794 0.0284 0.7020 0.9613 0.0689 0.9308 −0.3488 0.7143 0.2327 cytochrome P450 2J2-like
LOC100547885 0.0011 −0.9841 0.0000 −2.4195 0.0453 −0.6672 0.0321 0.7153 UDP-glucuronosyltransferase 1-1-like
LOC100548173 0.0000 3.7249 0.0000 2.5969 1.0000 −0.3391 0.1461 0.7080 galactosylgalactosylxylosylprotein 3-betaglucuronosyltransferase 1-like
LOC100548279 0.0000 −7.9193 0.0000 −11.0735 0.5445 −0.5533 0.0906 2.5242 cytochrome P450 2K4-like
LOC100548322 0.0000 −5.6388 0.0000 −7.6409 0.0002 −1.2226 0.0429 0.7206 cytochrome P450 2D17
LOC100548433 0.0000 −5.3627 0.0000 −8.5915 1.0000 −0.1464 0.0000 3.0249 cytochrome P450 2K1-like
LOC100548965 0.0027 1.2412 0.4561 0.2791 0.5805 0.4725 0.0144 1.3798 cytochrome P450 2J3-like
LOC100549160 0.0000 −1.5607 0.0000 −1.7517 0.0335 −0.7103 0.3717 −0.5706 cytochrome P450 4F22
LOC100549268 0.0000 2.8734 0.0067 1.6835 1.0000 −0.3799 0.2658 0.7421 aldehyde oxidase 2-like
LOC100549312 0.3177 0.3574 0.0000 −1.5738 0.0000 −1.9158 1.0000 −0.0363 UDP-glucuronosyltransferase 2C1-like
LOC100549991 0.0000 −1.7655 0.0000 −1.6943 0.0002 1.3894 0.0039 1.2611 arylamine N-acetyltransferase, liver isozyme
LOC100550430 0.0512 −0.6659 0.0000 −1.3736 0.2945 −0.4855 0.9495 0.1737 cytochrome P450 4F22
LOC104909216 0.0925 3.6677 0.0207 4.6262 1.0000 0.0000 0.5908 −1.0481 cytochrome P450 2J6-like
LOC104909734 0.0000 −6.4443 0.0023 −2.1011 0.0000 4.1441 1.0000 −0.2356 sulfotransferase family cytosolic 2B member 1-like
LOC104910746 0.0000 −3.6385 0.0000 −5.1988 0.7764 −0.3620 0.1896 1.1405 alcohol dehydrogenase 1-like
LOC104911955 0.3696 −0.4051 0.0000 −1.7954 0.0045 −1.2985 1.0000 0.0458 cytochrome P450 2H2
LOC104912373 0.0000 6.1224 0.0000 7.7909 0.2163 2.2765 0.2724 0.5912 sulfotransferase 6B1-like
LOC104912427 0.0001 0.8626 0.0006 0.8049 0.7651 −0.3468 0.3464 −0.3463 cytochrome P450 2J2-like
LOC104912428 0.1738 0.5765 1.0000 0.0281 0.2879 0.5209 0.0401 1.0161 cytochrome P450 2J2-like
LOC104912494 0.0006 1.5962 0.0373 0.5871 1.0000 −0.1563 0.3537 0.7988 cytochrome P450 2J2-like
LOC104915391 0.0000 −4.4041 0.0000 −4.5429 1.0000 0.2453 0.9573 0.3281 sulfotransferase family cytosolic 2B member 1-like
LOC104915445 0.0000 −3.6108 0.0000 −4.2325 0.0262 −0.8559 0.9682 −0.2891 alcohol dehydrogenase 1-like
LOC104915446 0.0000 −3.8678 0.0000 −5.4661 0.1525 −0.6518 0.4129 0.8857 alcohol dehydrogenase 1-like
LOC104915473 0.0000 1.5141 0.8643 0.0874 0.8777 −0.3084 0.0010 1.0674 UDP-glucuronosyltransferase 1-9-like
LOC104915474 0.8756 −0.1560 0.0000 −3.7112 0.0000 −2.5312 0.0418 0.9617 UDP-glucuronosyltransferase 1-6-like
LOC104915476 0.0006 1.6704 0.9112 0.1504 0.4764 −1.0151 0.6292 0.4445 UDP-glucuronosyltransferase 1-1-like
LOC104915477 0.0000 −4.3026 0.0000 −6.1630 1.0000 0.0675 0.0160 1.8961 UDP-glucuronosyltransferase 1-6 pseudogene
LOC104915478 0.0000 −1.7304 0.0000 −3.7892 1.0000 0.1939 0.0017 2.2036 UDP-glucuronosyltransferase 1-1-like
LOC104915479 0.0000 −2.4027 0.0000 −5.5537 0.1838 −0.9621 0.0384 2.1351 cytochrome P450 2H1-like
LOC104915586 0.0000 −5.9323 0.0090 −2.7687 0.0023 3.1518 1.0000 −0.0267 sulfotransferase family cytosolic 2B member 1-like
LOC104915609 0.0022 −3.8661 0.0686 −3.9012 0.8037 1.2048 1.0000 1.5781 cytochrome P450 2C19-like
LOC104915610 0.0000 3.8631 0.0000 3.5278 0.9437 −0.6231 0.9255 −0.3368 cytochrome P450 2C4-like
LOC104916399 0.0000 −6.0701 0.0000 −7.5516 0.5648 0.6141 0.4295 2.0569 cytochrome P450 2C27-like
LOC104916553 0.0000 −4.9703 0.0000 −3.9795 0.5369 0.6853 0.9367 −0.3716 sulfotransferase family cytosolic 2B member 1-like
LOC104916909 0.0000 −5.6085 0.0000 −7.0458 0.5315 0.5373 0.1227 1.9411 cytochrome P450 2C31-like
NQO1 0.7812 −0.1408 0.0008 −0.8283 1.0000 −0.1435 0.2145 0.4945 NAD(P)H dehydrogenase, quinone 1
NQO2 0.0000 −0.9071 0.4267 −0.2242 0.4389 0.3990 0.5130 −0.3430 NAD(P)H dehydrogenase, quinone 2
PTGS1 0.0000 1.4444 0.1729 0.5413 0.9517 −0.4782 0.5266 0.3552 prostaglandin-endoperoxide synthase 1
PTGS2 0.7963 0.1315 0.0000 1.3365 0.1157 0.7544 0.1495 −0.5069 prostaglandin-endoperoxide synthase 2
SULT4A1 0.1141 −0.6315 0.0039 −0.8113 1.0000 0.3027 0.4515 0.4192 sulfotransferase family 4A, member 1
SULT6B1 0.0457 −1.6954 0.0001 −2.6041 1.0000 0.0540 0.7545 0.9577 sulfotransferase family, cytosolic, 6B, member 1
TPMT 0.9701 0.0725 0.0017 −0.7106 0.8466 −0.2968 0.2312 0.4402 thiopurine S-methyltransferase
UGT8 0.0000 1.7926 0.0000 1.1497 0.5752 −0.3194 0.6356 0.2705 UDP glycosyltransferase 8

Genes included were significant (FDR p-value < 0.05) in at least one comparison. Comparisons highlighted in green are down regulated and those in red up regulated. Cytochrome P450 (CYP) and glutathione S-transferase (GST) family members shown to have in vitro activity towards AFB1 and its metabolites in turkey are indicated in bold. * Due to similarity, these likely include transcripts assignable to GSTA1.1, A1.2, and A1.3.