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. 2018 Jan 16;9(1):39. doi: 10.3390/genes9010039

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Induced pluripotent stem cells (iPSC) DNA methylation landscape composition. As reported by Lister et al. [39], average DNA methylation (DNAm) values of iPSCs resembles those of embryonic stem cell-like (hESCs). An extremely limited percentage of the sequenced DNA subjected to sodium bisulfite conversion (MethylC-seq) (0.002%) harbours differentially methylated regions (DMRs) (1175 in total). CG-DMRs are subdivided into: De Novo (51–56%) DMRSs which differ both from the parental cell line and hESC and are specific and unique for each iPSC line; and Memory (44–49%) DMRs, which are similar to the parental cell line but not hESC and can be associated either to the parental cell age, type, or could be specific to the parental cell type donor.