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. 2018 Jan 16;9(1):39. doi: 10.3390/genes9010039

Figure 2.

Figure 2

Model of epigenetic and functional rejuvenation hypothesis. During embryonic development, cells undergo a continuous epigenetic and molecular reshaping that ultimately define their function and their anatomical localisation. Cellular reprogramming is a large-scale remodelling procedure that erases most (but not all) of the features defining a cell’s identity. This leads to hESC-like cells that present with altered maturative potential.