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. 2018 Jan 16;9(1):40. doi: 10.3390/genes9010040

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Images copied from the National Center for Bioinformation of the United States (NCBI) database illustrating that some human genomic loci are crowded gene habitats. Within the GPHN gene (the long red arrow in the top image) on the plus DNA strand (arrow to the right) of the 14q23.3–24.1 region, there are also many other genes encoded not only by the same plus strand (short grey arrows to the right) but also by the minus strand (short grey arrows to the left). Similarly, within the POTEI gene (the long red arrow in the bottom image) on the minus DNA strand (arrow to the left) of the 2q21.1 region, there are also many other genes encoded not only by the same minus strand (short grey arrows to the left) but also by the plus strand (short grey arrows to the right). Some of these genes are temporarily annotated with “LOC” (locus) and a number, since they have not yet been characterized.