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. 2018 Jan 16;9(1):40. doi: 10.3390/genes9010040

Figure 4.

Figure 4

Images copied and modified from the NCBI database illustrating that one human genomic locus harbors two genes whose RNAs not only are transcribed from the same initiation site but also share exons. Top panel: The CERS1 and GDF1 genes are encoded by the same human genomic locus at the 19p13.11 region, and the GDF1 mRNA is identical to the largest CERS1 mRNA, but the same mRNA codes for different open reading frames (ORFs) for the GDF1 and the CERS1 genes. Middle panel: The CPNE1 and RBM12 genes are encoded by the same genomic locus at the human 20q11.22 region and are transcribed from the same initiation site. While the CPNE1 transcripts may be cis-spliced to six mRNAs and one noncoding RNA, the RBM12 transcripts may be cis-spliced to four mRNAs. The CPNE1 RNAs share some exons with the RBM12 RNAs. Bottom panel: The three mRNAs and one noncoding RNA of the IL4I1 gene share some exons with the five mRNAs of the NUP62 gene, and both genes locate at the same genomic locus in the human 19q13.33 region, with some RNAs of these two genes sharing the same transcription initiation site.