Table 1. Univariate analysis of association of CMI levels with pCR.
| CMI* | Tissue | Serum | ||||
|---|---|---|---|---|---|---|
| n | OR (95% CI) | P-value | n | OR (95% CI) | P-value | |
| Baseline | 58 | 0.73 (0.49, 1.09) | 0.129 | 59 | 1.17 (0.82, 1.67) | 0.400 |
| D15 | 50 | 0.60 (0.37, 0.97) | 0.037 | 61 | 0.9 (0.57, 1.42) | 0.652 |
| Change from baseline | 48 | 0.52 (0.26, 1.05) | 0.069 | 58 | 0.83 (0.57, 1.21) | 0.324 |
*
Natural log transformed
Change from baseline, change of CMI defined as log (D15 CMI+1/Baseline CMI+1); n, number of available samples; CI, confidence interval; CMI, cumulative methylation index; D15, 15 days after the first treatment; OR, odds ratio