Figure 1.

Representation of significant methylation changes of cg01081346. (a) Methylation mean and SD of each dietary group at baseline and at 5 years. Statistical analysis was performed by a Student-t test between 5 years and baseline for each diet. (b) Methylation changes (Mean and SD) for each participant and diet. Statistical analysis of differences in methylation changes among diets was performed by ANOVA (+Tukey’s multiple comparison test). Significance is considered * p < 0.05, *** p < 0.001. (c) Regression graph representing the relation between methylation changes and nuts intake at 5 years. Dot lines on both sides of the solid line (linear regression line) represent 95% confidence band. MedDiet: Mediterranean diet.