Figure 2.

Proposed roles of zinc in MG53 mediated wound healing process. MG53 exists as intrinsic intracellular vesicles which could be secreted into blood circulation as a myokine to mediate wound healing. In response to dermal injury, MG53 could exert the following functions. (a) MG53-containing vesicles nucleate the cell membrane repair machinery and trafficking to damaged cell membrane to protect against acute membrane injury of keratinocytes and fibroblasts; (b) MG53 mediates cytoskeletal stress fibre remodelling to promote fibroblasts migration to the wound sites; and (c) MG53 regulates TGFβ signalling to modulate trans-differentiation of fibroblasts into myofibroblasts and suppresses deposition of ECM proteins during tissue remodelling stage of wound healing. Zinc is proposed to bind to MG53 on its two zinc-binding sites and modulates MG53-mediated wound healing process (Modified from JBC 290(40): 24592). MG53: Mitsugumin 53; ECM: extracellular matrix; TGFβ: transforming growth factor-β.