Figure 2.

Effect of GEE on fasting blood glucose in db/db mice. Prior to measurement, five-week-old mice were fasted for 12 h during the dark period. Blood glucose levels were measured weekly. The mice were treated with or without GEE (50 and 200 mg/kg/day) (A). Area under the curve for glucose (AUC glucose) was calculated using the trapezoidal rule (B). Differences between time-points and treatments were analyzed by two-way ANOVA followed by Tukey’s multiple comparisons post hoc test. Data are mean ± SD. (n = 8 per group, ^a p < 0.05, ^b p < 0.01, ^c p < 0.001).