Table 3.
Effect of GEE on blood biochemistry in db/db mice. LDL: low-density lipoprotein; HbA1c: hemoglobin A1c.
| Group | Blood Biochemistry | |||||
|---|---|---|---|---|---|---|
| db/+ | db/db | |||||
| Parameters | GEE 0 * | GEE 0 * | GEE 0 * | GEE 50 * | GEE 200 * | |
| Metformin 0 * | Metformin 0 * | Metformin 140 * | Metformin 0 * | Metformin 0 * | ||
| Insulin | 0.17 ± 0.08 b | 1.06 ± 0.54 a | 0.52 ± 0.20 ab | 0.91 ± 0.20 a | 0.58 ± 0.30 ab | |
| C-peptide | 35.7 ± 25.8 b | 336.0 ± 168.0 a | 178.2 ± 97.3 ab | 159.3 ± 167.4 b | 145.2 ± 57.0 b | |
| HbA1c (ng/mL) | 14.6 ± 2.5 b | 28.0 ± 4.1 a | 19.7 ± 1.9 bc | 21.7 ± 2.0 b | 16.1 ± 4.2 cd | |
| LDL (mg/dL) | 14.7 ± 0.3 | 14.4 ± 1.0 | 14.5 ± 0.9 | 14.4 ± 1.4 | 14.1 ± 0.9 | |
| Triglyceride (mg/dL) | 75.3 ± 8.0 b | 341.5 ± 97.2 a | 282.2 ± 108.5 a | 237.5 ± 136.9 a | 315.8 ± 174.0 a | |
| T. cholesterol (mg/dL) | 95.1 ± 9.1 b | 177.8 ± 24.0 a | 156.7 ± 21.9 a | 157.8 ± 33.5 a | 152.7 ± 15.6 a | |
* (mg/kg/day), (n = 8 per group, a p < 0.05, b p < 0.01, c p < 0.001).