Table 2.
Cox proportional hazards for cancer and mortality for genetic risk score of alleles associated with an increase in circulating 25OHD (continuous and categorical) *.
| Cases/Sample Size | Rate/1000 pyrs 1 | HR (95% CI) | |
|---|---|---|---|
| Breast | |||
| Continuous | 1560/23,294 | 1.02 (0.99–1.05) | |
| Reference | 417/6477 | 3.56 | 1.00 |
| GRS 6–7 | 626/9619 | 3.60 | 1.02 (0.90–1.15) |
| GRS 8–10 | 517/7196 | 4.00 | 1.13 (0.99–1.28) |
| Colorectal | |||
| Continuous | 329/23,294 | 1.06 (1.00–1.13) | |
| Reference | 83/6477 | 0.69 | 1.00 |
| GRS 6–7 | 136/9621 | 0.76 | 1.12 (0.85–1.47) |
| GRS 8–10 | 110/7195 | 0.82 | 1.21 (0.91–1.61) |
| Lung | |||
| Continuous | 330/23,294 | 1.00 (0.94–1.06) | |
| Reference | 99/6477 | 0.82 | 1.00 |
| GRS 6–7 | 129/9621 | 0.72 | 0.89 (0.68–1.15) |
| GRS 8–10 | 102/7196 | 0.76 | 0.94 (0.71–1.23) |
| Total | |||
| Continuous | 3985/23,294 | 1.01 (1.00–1.03) | |
| Reference | 1091/6468 | 9.71 | 1.00 |
| GRS 6–7 | 1626/9610 | 9.76 | 1.01 (0.93–1.09) |
| GRS 8–10 | 1268/7183 | 10.23 | 1.06 (0.98–1.15) |
| Total Mortality | |||
| Continuous | 2973/23,294 | 1.00 (0.98–1.02) | |
| Reference | 850/6477 | 6.87 | 1.00 |
| GRS 6–7 | 1193/9621 | 6.49 | 0.96 (0.88–1.05) |
| GRS 8–10 | 930/7196 | 6.77 | 1.00 (0.91–1.09) |
| Cancer mortality | |||
| Continuous | 770/23,294 | 1.00 (0.96–1.04) | |
| Reference | 217/6468 | 1.93 | 1.00 |
| GRS 6–7 | 305/9610 | 1.83 | 0.95 (0.80–1.13) |
| GRS 8–10 | 248/7183 | 2.00 | 1.05 (0.87–1.26) |
* Adjusted for age; Reference is genetic risk score (GRS) = 0–5. 1 Person-years (pyrs).