Effect of the Stauntonia hexaphylla fruit (SHF) extract on carrageenan-induced rat paw edema. SHF extract was administered in a quantity of 50, 100 and 200 mg/kg for 3 days before the carrageenan injection (1% carrageenan suspended in saline), whereas celecoxib (60 mg/kg, positive control, p.o.) was administered 1 h before the carrageenan injection. Subsequently, 1 h after treatment, 1% carrageenan was injected into the right hind paw of each rat. The left paw was used as a control (0.1 mL saline injected). Edema was measured at 0 h, 1 h, 3 h and 5 h after injection of carrageenan using a plethysmometer (Ugo Basile, Comerio, Italy). Data are presented as means ± SD (n = 5). * p < 0.05 and ** p < 0.01 as compared with 1% Carrageenan group (ANOVA followed Dunnett’s test).