Table 2.
Relative permeability of organoids as well as mRNA and protein expression of TJ proteins
| Organoid Permeability | Cldn2 | Cldn7 | Ocln | ZO1 | Cdh1 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| mRNA | Protein | mRNA | Protein | mRNA | Protein | mRNA | Protein | mRNA | Protein | ||
| ISC | + | ++++ | ++++ | + | ++ | ++++ | ++ | +++ | +++ | +++ | ++++ |
| ENT | ++++ | ++ | + | ++++ | ++++ | +++ | + | +++ | ++ | ++ | +++ |
| GOB | ++++ | + | - | ++ | +++ | +++ | - | +++ | ++ | ++ | ++++ |
| PAN | + | +++ | ++ | +++ | ++++ | ++++ | +++ | ++++ | + | ++++ | ++++ |
- = no expression, + = low, ++ = modest, +++ = high, ++++ = very high expression
Cldn claudin, ENT enterocyte, GOB goblet cell, ISC intestinal stem cell, PAN Paneth cell, TJ tight junction, ZO-1 tight junction protein-1