Table 1.
ROTEM and standard coagulation profiles results, before and 24 h after hydroxyethyl starch 130/0.4 infusion
| GROUP 1 (1 ml / kg / h) N = 11 | GROUP 2 (2 ml / kg / h) N = 9 | Institutional reference ranges | |||
|---|---|---|---|---|---|
| ROTEM | T0 | T1 | T0 | T1 | |
| In-TEM® | |||||
| CT (s) | 180 (132–268) | 166 (61–209) | 188 (112–279) | 141 (108–240) | 126–363 s |
| CFT (s) | 63 (45–132) | 59 (41–113) | 73 (41–86) | 58 * (38–81) | 47–224 s |
| MCF (mm) | 72 (56–80) | 72 (58–88) | 68 (62–77) | 72 (62–78) | 50–75 mm |
| α angle (°) | 77 (65–81) | 79 (69–82) | 76 (73–82) | 78 * (74–82) | 55–81 ° |
| Ex-TEM® | |||||
| CT (s) | 44 (27–61) | 45 (20–77) | 46 (30–89) | 40 (33–80) | 29–92 s |
| CFT (s) | 67 (38–159) | 78 (49–132) | 81 (51–96) | 62 (49–92) | 54–275 s |
| MCF (mm) | 77 (60–82) | 70 (64–83) | 70 (66–81) | 72 * (67–86) | 36–73 mm |
| α angle (°) | 76 (61–83) | 76 (65–82) | 74 (71–80) | 77 * (73–81) | 47–79 ° |
| Fib-TEM® | |||||
| CT (s) | 47 (31–107) | 39 (21–57) | 45 (29–92) | 39 (32–80) | 14–102 s |
| MCF (mm) | 25 (7–38) | 16 (8–46) | 15 (9–30) | 20 (14–78) | 6–26 mm |
| α angle (°) | 77,5 (70–86) | 76 (30–86) | 76,5 (67–81) | 77 (71–84) | 40–78 ° |
| MCEplatelet | 294 (142–404) | 211 (169–441) | 206 (175–383) | 235 (183–571) | 50–235 |
| Standard coagulation | |||||
| aPTT (s) | 12.5 (9.6–15.4) | 12.3 (8.7–16) | 13.9 (12.1–16) | 14.5 (11.7–16) | 12–16 s |
| PT (s) | 7.5 (6.6–9.6) | 7.15 (6.6–9.9) | 7.4 (6.2–10) | 7.3 (6.3–10) | 8–10 s |
| Fibrinogen (g/L) | 3.5 (2.5–8.5) | 3.6 (2.4–7.9) | 3.4 (2.2–7.4) | 4.1 (2.2–7.1) | 1.5–4.50 (g/L) |
Values are expressed as median (minimum-maximum)
Values of institutional reference ranges for ROTEM parameters are expressed as 95% confidence intervals14
In-TEM® intrinsic thromboelastometry pathway, Ex-TEM® extrinsic thromboelastometry pathway, Fib-TEM® functional fibrinogen, CT clotting time, CFT clot formation time, MCF maximum clot firmness, PT prothrombin time, aPTT activated partial thromboplastin time
* Indicates statistically significant differences between T0 and T1 (P < 0.05)