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. 2018 Feb 1;13:15. doi: 10.1186/s13023-018-0762-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Time series of the annual number of DRD submission made to CDR over 12 years (for the period 2004 through 2016). a Number of annual submission for the entire period. b Illustration of the change in the number of submissions at the beginning 3 years of the period versus the last 3 years