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. 2018 Feb;10(2):a028415. doi: 10.1101/cshperspect.a028415

Figure 2.

Figure 2.

Molecular set-up of the interleukin-6 receptor (IL-6R) complex and comparison with other receptor complexes of IL-6 family cytokines. (A) IL-6 (red) binds to the membrane-bound IL-6R (red) and the complex of IL-6 and IL-6R associate with gp130 (lilac), which dimerizes and initiates signaling. (B) The IL-6 family cytokines act via four different ligand-binding receptors (left) and six different signaling receptors (right). (C) Assembly of the receptor complexes of the IL-6 family cytokines. CNTF, Ciliary neurotrophic factor; CLC, cardiotrophin-like cytokine; CT-1, cardiotrophin 1; LIF, leukemia inhibitory factor; OSM, oncostatin M.