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. 2018 Feb;28(2):145–158. doi: 10.1101/gr.225896.117

Figure 5.

Figure 5.

Sperm DNA methylation divergence is accompanied by sperm histone modification and DNA sequence divergence. (A) Mouse- and human-specific sperm HMRs and HMR extensions show species-specific H3K4me3 and H3K27me3 enrichment. (B) Lineage-specific HMRs are associated with relatively more sequence substitutions. For each pair of parallel lineages, expected distribution of RSSR is shown as a gray histogram, and fit is shown with normal distribution (black curve). The yellow area marks 90% confidence interval for mean RSSR. Upper (lower) tail of the distribution indicates significantly more substitutions in the numerator (denominator) lineage. Each lollipop marks the observed RSSR in HMRs specific to the indicated lineage, with one-sided P-value shown on top.