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. 2018 Feb;28(2):256–265. doi: 10.1101/gr.206938.116

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© 2018 Lowe et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Freshwater deletions in DCHS1 remove a conserved sequence that functions as a telencephalon enhancer. (A) The majority of freshwater populations do not have any reads (blue bars) mapping to a region within the first intron of DCHS1, but the marine populations (red bars) appear to universally contain this piece of DNA. The deleted region encompasses an element that shows cross-species conservation with medaka. (B) We cloned three copies of this region upstream of the HSP70 minimal promoter and GFP reporter to test its regulatory potential. (C) We injected this construct into fertilized eggs and multiple transgenic lines show GFP expression in the developing brain at 5 d post-fertilization (dotted white line shows the outline of the embryo within the egg).