Table 3.
P10 (Top Number) and P90 (Bottom Number) mPFC Gene Expression in Males
Gene |
CON |
HFD |
ANOVA | ||||
---|---|---|---|---|---|---|---|
Oil | 200 | 1000 | Oil | 200 | 1000 | ||
Endocrine system | |||||||
Ldlr | 0.94 ± 0.13 | 0.90 ± 0.14 | 0.95 ± 0.11 | 1.10 ± 0.12 | 1.17 ± 0.12 | 1.13 ± 0.12 | Diet, P = 0.050 |
1.57 ± 0.15 | 1.32 ± 0.14 | 1.28 ± 0.12 | 1.17 ± 0.13 | 1.40 ± 0.17 | 1.23 ± 0.15 | ||
Cyp11a1 | 2.25 ± 0.05 | 1.10 ± 0.52 | 1.72 ± 0.41 | 2.32 ± 0.43 | 1.22 ± 0.46 | 1.61 ± 0.43 | |
0.39 ± 0.17 | 0.41 ± 0.15 | 0.35 ± 0.12 | 0.56 ± 0.14 | 0.36 ± 0.18 | 0.37 ± 0.16 | ||
Star | 0.32 ± 0.05 | 0.30 ± 0.05 | 0.35 ± 0.04 | 0.35 ± 0.05 | 0.33 ± 0.05 | 0.29 ± 0.05 | |
0.56 ± 0.31 | 1.04 ± 0.27 | 0.89 ± 0.22 | 0.81 ± 0.24 | 0.84 ± 0.32 | 0.66 ± 0.28 | ||
Ar | 1.57 ± 0.51 | 1.27 ± 0.54 | 1.81 ± 0.42 | 1.45 ± 0.45 | 2.73 ± 0.48 | 1.06 ± 0.45 | Trt × diet, P = 0.006 |
1.34 ± 0.08 | 1.10 ± 0.08 | 1.00 ± 0.07 | 0.97 ± 0.07 | 1.14 ± 0.10 | 1.13 ± 0.09 | ||
Cyp19a1 | 1.51 ± 0.35 | 1.81 ± 0.37 | 2.10 ± 0.29 | 1.58 ± 0.30 | 1.98 ± 0.32 | 1.37 ± 0.30 | |
2.08 ± 0.33 | 1.83 ± 0.30 | 1.27 ± 0.24 | 1.88 ± 0.29 | 1.47 ± 0.35 | 1.44 ± 0.31 | ||
Esr1 | 0.84 ± 0.14 | 0.80 ± 0.14 | 0.75 ± 0.11 | 0.87 ± 0.11 | 0.58 ± 0.12 | 1.08 ± 0.11 | Diet, P = 0.001 |
1.72 ± 0.16 | 1.57 ± 0.14 | 1.30 ± 0.12 | 1.02 ± 0.14 | 1.11 ± 0.18 | 1.18 ± 0.16 | ||
Esr2 | 2.82 ± 0.53 | 2.82 ± 0.56 | 4.13 ± 0.43 | 3.29 ± 0.46 | 3.48 ± 0.50 | 3.28 ± 0.45 | Diet, P = 0.046 |
1.77 ± 0.20 | 1.20 ± 0.20 | 1.22 ± 0.17 | 0.90 ± 0.17 | 1.20 ± 0.23 | 1.08 ± 0.20 | ||
Esrrg | 1.62 ± 0.27 | 1.63 ± 0.28 | 1.87 ± 0.22 | 1.70 ± 0.23 | 2.32 ± 0.25 | 1.69 ± 0.25 | Trt, P = 0.033; diet, P = 0.016 |
1.29 ± 0.14 | 1.52 ± 0.12 | 1.10 ± 0.10 | 1.01 ± 0.11 | 1.18 ± 0.15 | 0.92 ± 0.13 | ||
Cd38 | 1.17 ± 0.09 | 1.15 ± 0.10 | 1.19 ± 0.08 | 1.20 ± 0.08 | 1.14 ± 0.09 | 1.18 ± 0.08 | |
1.33 ± 0.12 | 1.11 ± 0.11 | 1.00 ± 0.10 | 1.00 ± 0.11 | 1.22 ± 0.14 | 1.17 ± 0.14 | ||
Oxtr | 3.02 ± 0.63 | 3.00 ± 0.75 | 3.49 ± 0.52 | 2.68 ± 0.65 | 1.87 ± 0.58 | 3.27 ± 0.54 | |
1.28 ± 0.22 | 1.59 ± 0.22 | 1.09 ± 0.19 | 0.77 ± 0.21 | 1.29 ± 0.26 | 1.14 ± 0.23 | ||
Avpr1a | 0.19 ± 0.03 | 0.22 ± 0.03 | 0.20 ± 0.02 | 0.18 ± 0.02 | 0.17 ± 0.02 | 0.24 ± 0.02 | |
1.16 ± 0.17 | 0.98 ± 0.17 | 0.98 ± 0.13 | 0.90 ± 0.15 | 0.96 ± 0.20 | 0.93 ± 0.17 | ||
Avpr1b | 1.72 ± 0.25 | 1.13 ± 0.29 | 1.26 ± 0.21 | 1.67 ± 0.22 | 1.39 ± 0.25 | 1.03 ± 0.22 | |
1.44 ± 0.34 | 1.03 ± 0.29 | 0.75 ± 0.24 | 0.75 ± 0.24 | 1.21 ± 0.31 | 1.12 ± 0.31 | ||
Thra | 1.98 ± 0.19 | 2.22 ± 0.20 | 1.97 ± 0.16 | 2.11 ± 0.17 | 2.08 ± 0.17 | 2.38 ± 0.16 | Trt, P = 0.030 |
1.79 ± 0.15 | 1.69 ± 0.15 | 1.32 ± 0.12 | 1.35 ± 0.13 | 1.75 ± 0.17 | 1.35 ± 0.15 | ||
Defense system | |||||||
Ahr | 0.44 ± 0.16 | 0.61 ± 0.16 | 0.45 ± 0.13 | 0.57 ± 0.13 | 0.37 ± 0.14 | 0.60 ± 0.13 | |
0.77 ± 0.14 | 0.80 ± 0.13 | 0.78 ± 0.10 | 0.70 ± 0.11 | 0.76 ± 0.15 | 0.69 ± 0.13 | ||
Cat | 0.26 ± 0.02 | 0.25 ± 0.03 | 0.23 ± 0.02 | 0.27 ± 0.02 | 0.30 ± 0.02 | 0.30 ± 0.02 | Diet, P = 0.022 |
1.37 ± 0.11 | 1.19 ± 0.10 | 1.12 ± 0.08 | 1.11 ± 0.09 | 1.33 ± 0.11 | 1.17 ± 0.10 | ||
Glrx | 1.64 ± 0.14 | 1.89 ± 0.15 | 1.54 ± 0.12 | 1.58 ± 0.12 | 1.48 ± 0.13 | 1.61 ± 0.12 | |
1.64 ± 0.19 | 1.53 ± 0.17 | 1.31 ± 0.13 | 1.26 ± 0.15 | 1.59 ± 0.19 | 1.04 ± 0.17 | ||
Sod1 | 1.60 ± 0.19 | 1.52 ± 0.20 | 1.69 ± 0.16 | 1.40 ± 0.17 | 1.81 ± 0.20 | 1.88 ± 0.17 | |
1.36 ± 0.12 | 1.20 ± 0.11 | 1.21 ± 0.10 | 1.10 ± 0.11 | 1.38 ± 0.14 | 1.42 ± 0.12 | ||
Sod2 | 1.83 ± 0.29 | 1.72 ± 0.30 | 2.08 ± 0.26 | 2.06 ± 0.23 | 1.97 ± 0.30 | 2.10 ± 0.24 | |
1.00 ± 0.12 | 1.28 ± 0.11 | 0.98 ± 0.09 | 0.86 ± 0.10 | 0.98 ± 0.13 | 0.89 ± 0.12 | ||
Sod3 | 1.76 ± 0.54 | 1.73 ± 0.57 | 2.15 ± 0.44 | 1.59 ± 0.47 | 2.65 ± 0.55 | 1.46 ± 0.47 | Trt, P = 0.029 |
2.31 ± 0.25 | 2.09 ± 0.23 | 1.50 ± 0.20 | 1.62 ± 0.22 | 2.14 ± 0.29 | 1.49 ± 0.26 | ||
Inflammation | |||||||
Ifng | 1.04 ± 0.29 | 1.22 ± 0.28 | 1.13 ± 0.23 | 1.32 ± 0.25 | 0.81 ± 0.26 | 1.01 ± 0.27 | |
0.46 ± 0.22 | 0.47 ± 0.19 | 0.65 ± 0.15 | 0.11 ± 0.19 | 0.39 ± 0.25 | 0.25 ± 0.20 | ||
Il1b | 0.37 ± 0.09 | 0.20 ± 0.10 | 0.36 ± 0.08 | 0.27 ± 0.08 | 0.25 ± 0.08 | 0.20 ± 0.08 | |
1.56 ± 0.70 | 2.84 ± 0.55 | 3.18 ± 0.48 | 2.53 ± 0.47 | 2.09 ± 0.64 | 2.14 ± 0.56 | ||
Il6 | 1.23 ± 0.70 | 2.20 ± 0.69 | 2.57 ± 0.53 | 1.86 ± 0.57 | 2.95 ± 0.60 | 1.23 ± 0.60 | |
0.76 ± 0.09 | 0.66 ± 0.08 | 0.68 ± 0.07 | 0.60 ± 0.07 | 0.56 ± 0.10 | 0.64 ± 0.09 | ||
Tnf | 1.20 ± 0.16 | 1.23 ± 0.17 | 1.30 ± 0.13 | 1.48 ± 0.14 | 1.39 ± 0.15 | 1.25 ± 0.14 | |
0.32 ± 0.19 | 0.62 ± 0.17 | 0.76 ± 0.16 | 0.85 ± 0.15 | 0.81 ± 0.22 | 0.61 ± 0.18 | ||
Apoptosis | |||||||
Bad | 1.38 ± 0.11 | 1.39 ± 0.11 | 1.37 ± 0.09 | 1.33 ± 0.09 | 1.36 ± 0.10 | 1.49 ± 0.09 | |
1.60 ± 0.15 | 1.40 ± 0.13 | 1.45 ± 0.10 | 1.02 ± 0.11 | 1.46 ± 0.15 | 1.34 ± 0.13 | ||
Bcl2 | 1.49 ± 0.24 | 1.28 ± 0.26 | 1.50 ± 0.20 | 1.32 ± 0.21 | 1.59 ± 0.25 | 1.29 ± 0.21 | |
1.83 ± 0.24 | 1.34 ± 0.19 | 1.31 ± 0.15 | 1.02 ± 0.19 | 1.36 ± 0.22 | 1.13 ± 0.20 | ||
Casp3 | 1.36 ± 0.18 | 1.24 ± 0.19 | 1.26 ± 0.15 | 1.33 ± 0.16 | 1.17 ± 0.17 | 1.60 ± 0.16 | |
1.46 ± 0.15 | 1.36 ± 0.14 | 1.18 ± 0.11 | 1.11 ± 0.12 | 1.45 ± 0.16 | 1.16 ± 0.14 | ||
Dopamine receptors | |||||||
Drd1 | 1.13 ± 0.28 | 1.44 ± 0.29 | 1.53 ± 0.23 | 0.96 ± 0.26 | 1.54 ± 0.31 | 1.53 ± 0.24 | |
1.15 ± 0.18 | 1.38 ± 0.15 | 1.15 ± 0.13 | 1.25 ± 0.14 | 1.28 ± 0.19 | 1.01 ± 0.19 | ||
Drd2 | 0.66 ± 0.30 | 0.81 ± 0.32 | 1.43 ± 0.25 | 0.92 ± 0.28 | 1.76 ± 0.30 | 1.72 ± 0.28 | Trt, P = 0.025; diet, P = 0.038 |
0.79 ± 0.28 | 1.18 ± 0.23 | 0.94 ± 0.20 | 0.79 ± 0.22 | 0.84 ± 0.29 | 0.91 ± 0.26 |
Values are means ± standard error of the mean. Data are expressed as the ratio to L7a.
Abbreviation: Trt, treatment.