Table 4.
P10 (Top Number) and P90 (Bottom Number) mPFC Gene Expression in Females
| Gene |
CON |
HFD |
ANOVA | ||||
|---|---|---|---|---|---|---|---|
| Oil | 200 | 1000 | Oil | 200 | 1000 | ||
| Endocrine system | |||||||
| Ldlr | 0.91 ± 0.15 | 0.95 ± 0.17 | 1.09 ± 0.13 | 1.07 ± 0.16 | 0.98 ± 0.17 | 1.02 ± 0.18 | |
| 1.40 ± 0.16 | 1.34 ± 0.20 | 1.23 ± 0.15 | 1.38 ± 0.19 | 1.30 ± 0.23 | 1.25 ± 0.19 | ||
| Cyp11a1 | 2.50 ± 0.42 | 1.66 ± 0.47 | 1.85 ± 0.37 | 2.15 ± 0.45 | 1.00 ± 0.47 | 1.43 ± 0.50 | |
| 0.39 ± 0.13 | 0.47 ± 0.15 | 0.39 ± 0.12 | 0.73 ± 0.16 | 0.36 ± 0.17 | 0.44 ± 0.14 | ||
| Star | 0.39 ± 0.07 | 0.41 ± 0.08 | 0.32 ± 0.07 | 0.39 ± 0.08 | 0.24 ± 0.08 | 0.29 ± 0.09 | |
| 0.61 ± 0.09 | 0.55 ± 0.12 | 0.86 ± 0.09 | 0.70 ± 0.11 | 0.69 ± 0.13 | 0.60 ± 0.12 | ||
| Ar | 1.69 ± 0.68 | 2.17 ± 0.75 | 1.11 ± 0.60 | 2.17 ± 0.73 | 0.57 ± 0.76 | 1.60 ± 0.92 | |
| 1.18 ± 0.12 | 1.06 ± 0.15 | 1.20 ± 0.11 | 1.17 ± 0.14 | 1.20 ± 0.16 | 1.01 ± 0.14 | ||
| Cyp19a1 | 1.34 ± 0.29 | 2.14 ± 0.32 | 1.87 ± 0.25 | 1.82 ± 0.31 | 1.23 ± 0.32 | 1.45 ± 0.34 | |
| 2.01 ± 0.32 | 1.10 ± 0.37 | 1.60 ± 0.30 | 1.23 ± 0.38 | 1.37 ± 0.41 | 1.14 ± 0.34 | ||
| Esr1 | 1.16 ± 0.13 | 0.88 ± 0.15 | 0.95 ± 0.12 | 0.80 ± 0.14 | 0.99 ± 0.15 | 0.78 ± 0.16 | |
| 1.23 ± 0.11 | 0.93 ± 0.13 | 1.15 ± 0.10 | 1.22 ± 0.12 | 1.17 ± 0.15 | 1.03 ± 0.12 | ||
| Esr2 | 2.56 ± 0.51 | 3.20 ± 0.63 | 2.75 ± 0.43 | 3.07 ± 0.63 | 2.28 ± 0.51 | 2.76 ± 0.56 | |
| 1.38 ± 0.16 | 1.02 ± 0.20 | 0.90 ± 0.15 | 1.14 ± 0.18 | 1.45 ± 0.22 | 1.11 ± 0.18 | ||
| Esrrg | 1.17 ± 0.30 | 1.76 ± 0.30 | 1.54 ± 0.24 | 1.98 ± 0.28 | 1.38 ± 0.30 | 1.10 ± 0.35 | |
| 1.35 ± 0.16 | 0.99 ± 0.19 | 1.21 ± 0.14 | 1.09 ± 0.19 | 1.09 ± 0.21 | 1.03 ± 0.17 | ||
| Cd38 | 1.40 ± 0.16 | 1.07 ± 0.17 | 1.09 ± 0.14 | 1.20 ± 0.17 | 1.05 ± 0.17 | 1.17 ± 0.19 | |
| 1.24 ± 0.12 | 1.14 ± 0.15 | 1.19 ± 0.12 | 0.92 ± 0.14 | 1.32 ± 0.17 | 1.07 ± 0.14 | ||
| Oxtr | 2.53 ± 0.62 | 3.34 ± 0.69 | 4.04 ± 0.61 | 2.57 ± 0.66 | 3.93 ± 0.77 | 2.12 ± 0.75 | Diet, P = 0.027 |
| 1.20 ± 0.20 | 1.34 ± 0.25 | 1.73 ± 0.20 | 1.16 ± 0.24 | 0.87 ± 0.28 | 0.89 ± 0.24 | ||
| Avpr1a | 0.20 ± 0.03 | 0.22 ± 0.03 | 0.21 ± 0.02 | 0.16 ± 0.03 | 0.24 ± 0.03 | 0.16 ± 0.03 | |
| 0.82 ± 0.10 | 0.73 ± 0.13 | 0.89 ± 0.09 | 0.94 ± 0.11 | 0.84 ± 0.13 | 0.86 ± 0.11 | ||
| Avpr1b | 1.81 ± 0.31 | 1.08 ± 0.34 | 2.10 ± 0.29 | 0.93 ± 0.33 | 1.27 ± 0.37 | 1.90 ± 0.37 | Trt, P = 0.045 |
| 1.41 ± 0.23 | 0.95 ± 0.33 | 1.42 ± 0.22 | 1.61 ± 0.27 | 1.45 ± 0.35 | 0.74 ± 0.22 | ||
| Thra | 1.91 ± 0.15 | 2.15 ± 0.17 | 2.12 ± 0.13 | 1.97 ± 0.16 | 2.14 ± 0.17 | 1.96 ± 0.18 | |
| 1.62 ± 0.16 | 1.34 ± 0.19 | 1.49 ± 0.14 | 1.34 ± 0.19 | 1.51 ± 0.21 | 1.29 ± 0.17 | ||
| Antioxidant defense systems | |||||||
| Ahr | 0.56 ± 0.16 | 0.54 ± 0.18 | 0.37 ± 0.14 | 0.49 ± 0.17 | 0.39 ± 0.18 | 0.31 ± 0.19 | |
| 0.93 ± 0.12 | 0.44 ± 0.15 | 0.57 ± 0.11 | 0.65 ± 0.15 | 0.79 ± 0.16 | 0.77 ± 0.14 | ||
| Cat | 0.28 ± 0.03 | 0.27 ± 0.03 | 0.25 ± 0.02 | 0.28 ± 0.03 | 0.25 ± 0.03 | 0.25 ± 0.03 | |
| 1.45 ± 0.14 | 1.15 ± 0.16 | 1.20 ± 0.14 | 0.95 ± 0.17 | 1.41 ± 0.18 | 1.15 ± 0.15 | ||
| Glrx | 1.44 ± 0.14 | 1.63 ± 0.16 | 1.92 ± 0.12 | 1.61 ± 0.15 | 1.57 ± 0.16 | 1.76 ± 0.17 | Trt × diet, P = 0.016 |
| 1.74 ± 0.17 | 1.14 ± 0.22 | 1.23 ± 0.17 | 0. 92 ± 0.21 | 1.50 ± 0.23 | 1.27 ± 0.19 | ||
| Sod1 | 1.36 ± 0.20 | 1.87 ± 0.23 | 1.34 ± 0.18 | 1.50 ± 0.22 | 1.58 ± 0.23 | 1.53 ± 0.24 | |
| 1.39 ± 0.13 | 1.22 ± 0.17 | 1.31 ± 0.13 | 1.06 ± 0.16 | 1.27 ± 0.19 | 1.09 ± 0.15 | ||
| Sod2 | 1.44 ± 0.23 | 1.86 ± 0.28 | 1.48 ± 0.21 | 2.20 ± 0.31 | 1.52 ± 0.25 | 1.46 ± 0.30 | |
| 1.14 ± 0.13 | 0.91 ± 0.16 | 0.97 ± 0.12 | 1.01 ± 0.15 | 0.97 ± 0.18 | 1.00 ± 0.15 | ||
| Sod3 | 1.61 ± 0.48 | 1.58 ± 0.54 | 1.23 ± 0.43 | 2.36 ± 0.52 | 1.31 ± 0.54 | 1.66 ± 0.58 | |
| 2.06 ± 0.26 | 1.53 ± 0.32 | 1.68 ± 0.24 | 1.79 ± 0.30 | 2.18 ± 0.36 | 1.22 ± 0.30 | ||
| Inflammation | |||||||
| Ifng | 1.36 ± 0.25 | 1.59 ± 0.26 | 1.52 ± 0.21 | 1.02 ± 0.25 | 1.19 ± 0.26 | 0.58 ± 0.31 | Diet, P = 0.012 |
| 0.44 ± 0.13 | 0.28 ± 0.16 | 0.46 ± 0.12 | 0.73 ± 0.17 | 0.32 ± 0.17 | 0.26 ± 0.14 | ||
| Il1b | 0.34 ± 0.06 | 0.28 ± 0.06 | 0.28 ± 0.05 | 0.35 ± 0.06 | 0.23 ± 0.06 | 0.31 ± 0.08 | |
| 3.60 ± 0.49 | 1.29 ± 0.62 | 2.30 ± 0.47 | 2.78 ± 0.60 | 2.46 ± 0.65 | 3.22 ± 0.58 | ||
| Il6 | 2.32 ± 0.46 | 0.75 ± 0.65 | 1.31 ± 0.43 | 2.05 ± 0.49 | 1.13 ± 0.51 | 1.90 ± 0.55 | |
| 0.89 ± 0.15 | 0.74 ± 0.17 | 0.70 ± 0.14 | 0.88 ± 0.18 | 0.70 ± 0.19 | 0.69 ± 0.16 | ||
| Tnf | 1.24 ± 0.16 | 1.20 ± 0.18 | 1.21 ± 0.14 | 1.48 ± 0.17 | 1.00 ± 0.18 | 1.34 ± 0.19 | |
| 0.91 ± 0.17 | 0.60 ± 0.22 | 0.63 ± 0.15 | 0.58 ± 0.21 | 0.67 ± 0.22 | 0.76 ± 0.19 | ||
| Apoptosis | |||||||
| Bad | 1.25 ± 0.08 | 1.45 ± 0.09 | 1.45 ± 0.07 | 1.37 ± 0.09 | 1.47 ± 0.09 | 1.32 ± 0.10 | Trt × diet, P = 0.050 |
| 1.49 ± 0.15 | 1.16 ± 0.19 | 1.32 ± 0.14 | 1.01 ± 0.18 | 1.61 ± 0.22 | 1.28 ± 0.16 | ||
| Bcl2 | 1.02 ± 0.29 | 1.65 ± 0.29 | 1.21 ± 0.23 | 1.60 ± 0.28 | 1.12 ± 0.29 | 1.17 ± 0.31 | |
| 1.49 ± 0.29 | 0.98 ± 0.37 | 1.21 ± 0.31 | 1.45 ± 0.38 | 1.40 ± 0.42 | 1.35 ± 0.31 | ||
| Casp3 | 1.25 ± 0.16 | 1.30 ± 0.18 | 1.39 ± 0.15 | 1.15 ± 0.18 | 1.69 ± 0.18 | 1.47 ± 0.20 | |
| 1.56 ± 0.15 | 1.25 ± 0.19 | 1.29 ± 0.15 | 1.01 ± 0.18 | 1.33 ± 0.20 | 1.17 ± 0.16 | ||
| Dopamine receptors | |||||||
| Drd1 | 1.08 ± 0.30 | 0.98 ± 0.30 | 1.30 ± 0.24 | 1.27 ± 0.32 | 0.91 ± 0.30 | 1.61 ± 0.32 | |
| 1.23 ± 0.19 | 1.57 ± 0.22 | 1.32 ± 0.17 | 1.16 ± 0.23 | 1.11 ± 0.25 | 1.18 ± 0.20 | ||
| Drd2 | 0.87 ± 0.25 | 0.42 ± 0.30 | 1.09 ± 0.20 | 0.97 ± 0.26 | 0.86 ± 0.25 | 1.23 ± 0.30 | |
| 0.77 ± 0.10 | 0.61 ± 0.11 | 0.78 ± 0.09 | 0.66 ± 0.12 | 0.82 ± 0.13 | 0.67 ± 0.11 | ||
Values are means ± standard error of the mean. Data are expressed as the ratio to L7a.
Abbreviation: Trt, treatment.